The Wilson Museum in Castine allows visitors to explore the natural history and cultures of the surrounding area. The Museum has a mission of building on the legacy of its founding family, using its diverse collections and learning experiences to stimulate exploration of the natural history and cultures of the Penobscot Bay region and the world.

The Wilson Museum is a museum in Castine, Maine, USA. It was founded using the collection of Dr John Howard Wilson, a geologist.

Wilson lived in Philadelphia, Brooklyn and Nantucket during his youth. He arrived at Castine in 1891 with his mother, Cassine Cartwright Wilson. He received a PhD in geology from Columbia University.

In 1921, Mrs Wilson gave the western part of the land she owned to build a museum for John Wilson's collections. Three other buildings were added in the late 1960s, the Blacksmith Shop, Hearse House, and the John Perkins House.

The exhibits include:

• Rocks, minerals, shells.
• Pre-historic artifacts from North and South America.
• Exhibits from Europe and Africa illustrating the development of tools during the early Paleolithic, Neolithic, Bronze and Iron ages.
• Six dioramas constructed by Ned Burns of the American Museum of Natural History in 1926.
• Cultures of Africa, Oceania, North and South America.
• Early weapons and firearms.
• Local history.
• Ship models.
• 19th century carpenter's tools, farm and household equipment.
• Reconstructed kitchen of 1805 and a Victorian parlor.
• Special exhibits every summer using the museum's collections.
• Archival material on the history of Castine.